diff --git a/chrome/content/zotero/bindings/itembox.xml b/chrome/content/zotero/bindings/itembox.xml
index 4bbbe6093f..ee63273f21 100644
--- a/chrome/content/zotero/bindings/itembox.xml
+++ b/chrome/content/zotero/bindings/itembox.xml
@@ -416,10 +416,12 @@
 						}
 						
 						// TEMP - NSF (homepage)
-						if ((fieldName == 'url' || fieldName == 'homepage') && val) {
+						if ((fieldName == 'url' || fieldName == 'homepage')
+								// Only make plausible HTTP URLs clickable
+								&& Zotero.Utilities.isHTTPURL(val, true)) {
 							label.classList.add("pointer");
 							// TODO: make getFieldValue non-private and use below instead
-							label.setAttribute("onclick", "ZoteroPane_Local.loadURI(this.nextSibling.firstChild ? this.nextSibling.firstChild.nodeValue : this.nextSibling.value, event)");
+							label.setAttribute("onclick", "Zotero.launchURL(this.nextSibling.firstChild ? this.nextSibling.firstChild.nodeValue : this.nextSibling.value)");
 							label.setAttribute("tooltiptext", Zotero.getString('locate.online.tooltip'));
 						}
 						else if (fieldName == 'DOI' && val && typeof val == 'string') {
diff --git a/chrome/content/zotero/xpcom/utilities.js b/chrome/content/zotero/xpcom/utilities.js
index 39d6dbafca..d677064f05 100644
--- a/chrome/content/zotero/xpcom/utilities.js
+++ b/chrome/content/zotero/xpcom/utilities.js
@@ -183,7 +183,13 @@ Zotero.Utilities = {
 		var x = x.replace(/^[\x00-\x27\x29-\x2F\x3A-\x40\x5B-\x60\x7B-\x7F\s]+/, "");
 		return x.replace(/[\x00-\x28\x2A-\x2F\x3A-\x40\x5B-\x60\x7B-\x7F\s]+$/, "");
 	},
-
+	
+	isHTTPURL: function (url, allowNoScheme = false) {
+		// From https://stackoverflow.com/a/3809435
+		var noSchemeRE = /^[-a-zA-Z0-9@:%._\+~#=]{1,256}\.[a-zA-Z0-9()]{1,6}\b([-a-zA-Z0-9()@:%_\+.~#?&//=]*)/;
+		return /^https?:\/\//.test(url) || (allowNoScheme && noSchemeRE.test(url));
+	},
+	
 	/**
 	 * Cleans a http url string
 	 * @param url {String}
diff --git a/chrome/content/zotero/xpcom/zotero.js b/chrome/content/zotero/xpcom/zotero.js
index db46d6151b..ca98cab9e7 100644
--- a/chrome/content/zotero/xpcom/zotero.js
+++ b/chrome/content/zotero/xpcom/zotero.js
@@ -1028,8 +1028,13 @@ Services.scriptloader.loadSubScript("resource://zotero/polyfill.js");
 	 * Used only by Standalone
 	 */
 	this.launchURL = function (url) {
-		if (!url.match(/^https?/)) {
-			throw new Error("launchURL() requires an HTTP(S) URL");
+		if (!Zotero.Utilities.isHTTPURL(url)) {
+			if (Zotero.Utilities.isHTTPURL(url, true)) {
+				url = 'http://' + url;
+			}
+			else {
+				throw new Error("launchURL() requires an HTTP(S) URL");
+			}
 		}
 		
 		try {
diff --git a/chrome/content/zotero/zoteroPane.js b/chrome/content/zotero/zoteroPane.js
index 3f76aae7a9..31f49a406a 100644
--- a/chrome/content/zotero/zoteroPane.js
+++ b/chrome/content/zotero/zoteroPane.js
@@ -3270,8 +3270,8 @@ var ZoteroPane = new function()
 				return;
 			}
 			
-			if(uri.match(/^https?/)) {
-				this.launchURL(uri);
+			if (uri.match(/^(chrome|resource):/)) {
+				Zotero.openInViewer(uri);
 				continue;
 			}
 			
@@ -3287,7 +3287,7 @@ var ZoteroPane = new function()
 				}
 			}
 			
-			Zotero.openInViewer(uri);
+			this.launchURL(uri);
 		}
 	}
 	
diff --git a/test/tests/utilitiesTest.js b/test/tests/utilitiesTest.js
index 81d035a3fb..d24450f017 100644
--- a/test/tests/utilitiesTest.js
+++ b/test/tests/utilitiesTest.js
@@ -34,6 +34,33 @@ describe("Zotero.Utilities", function() {
 	});
 	
 	
+	describe("#isHTTPURL()", function () {
+		it("should return true for HTTP URL", function () {
+			assert.isTrue(Zotero.Utilities.isHTTPURL('http://example.com'));
+		});
+		
+		it("should return true for HTTPS URL", function () {
+			assert.isTrue(Zotero.Utilities.isHTTPURL('https://example.com'));
+		});
+		
+		it("should return false for plausible HTTP URL if allowNoScheme not provided", function () {
+			assert.isFalse(Zotero.Utilities.isHTTPURL('example.com'));
+		});
+		
+		it("should return false for plausible HTTP URL if allowNoScheme is true", function () {
+			assert.isTrue(Zotero.Utilities.isHTTPURL('example.com', true));
+		});
+		
+		it("should return false for file URL", function () {
+			assert.isFalse(Zotero.Utilities.isHTTPURL('file:///c:/path/to/file.txt'));
+		});
+		
+		it("should return false for zotero: URL", function () {
+			assert.isFalse(Zotero.Utilities.isHTTPURL('zotero://select/library/items/AAAAAAAA'));
+		});
+	});
+	
+	
 	describe("#cleanDOI()", function () {
 		var cleanDOI = Zotero.Utilities.cleanDOI;
 		var doi = '10.1088/1748-9326/11/4/048002';