diff --git a/ts/components/stickers/StickerButton.tsx b/ts/components/stickers/StickerButton.tsx
index 242494b82c..353a93131f 100644
--- a/ts/components/stickers/StickerButton.tsx
+++ b/ts/components/stickers/StickerButton.tsx
@@ -116,7 +116,18 @@ export const StickerButton = React.memo(
           setPopperRoot(root);
           document.body.appendChild(root);
           const handleOutsideClick = ({ target }: MouseEvent) => {
-            if (!root.contains(target as Node)) {
+            const targetElement = target as HTMLElement;
+            const className = targetElement
+              ? targetElement.className || ''
+              : '';
+
+            // We need to special-case sticker picker header buttons, because they can
+            //   disappear after being clicked, which breaks the .contains() check below.
+            const isMissingButtonClass =
+              !className ||
+              className.indexOf('module-sticker-picker__header__button') < 0;
+
+            if (!root.contains(targetElement) && isMissingButtonClass) {
               setOpen(false);
             }
           };