diff --git a/chromium_src/BUILD.gn b/chromium_src/BUILD.gn
index 60fb38aab58d..a9a7cee308ef 100644
--- a/chromium_src/BUILD.gn
+++ b/chromium_src/BUILD.gn
@@ -85,6 +85,8 @@ static_library("chrome") {
     "//chrome/browser/process_singleton.h",
     "//chrome/browser/process_singleton_internal.cc",
     "//chrome/browser/process_singleton_internal.h",
+    "//chrome/browser/serial/serial_blocklist.cc",
+    "//chrome/browser/serial/serial_blocklist.h",
     "//chrome/browser/themes/browser_theme_pack.cc",
     "//chrome/browser/themes/browser_theme_pack.h",
     "//chrome/browser/themes/custom_theme_supplier.cc",
@@ -144,6 +146,8 @@ static_library("chrome") {
     "//chrome/browser/ui/views/overlay/video_overlay_window_views.h",
     "//chrome/browser/ui/webui/accessibility/accessibility_ui.cc",
     "//chrome/browser/ui/webui/accessibility/accessibility_ui.h",
+    "//chrome/browser/usb/usb_blocklist.cc",
+    "//chrome/browser/usb/usb_blocklist.h",
     "//extensions/browser/app_window/size_constraints.cc",
     "//extensions/browser/app_window/size_constraints.h",
     "//ui/base/accelerators/global_accelerator_listener/global_accelerator_listener.cc",
diff --git a/docs/breaking-changes.md b/docs/breaking-changes.md
index 3d570fda9e77..f0556a639aa1 100644
--- a/docs/breaking-changes.md
+++ b/docs/breaking-changes.md
@@ -14,6 +14,12 @@ This document uses the following convention to categorize breaking changes:
 
 ## Planned Breaking API Changes (37.0)
 
+### Behavior Changed: WebUSB and WebSerial Blocklist Support
+
+[WebUSB](https://developer.mozilla.org/en-US/docs/Web/API/WebUSB_API) and [Web Serial](https://developer.mozilla.org/en-US/docs/Web/API/Web_Serial_API) now support the [WebUSB Blocklist](https://wicg.github.io/webusb/#blocklist) and [Web Serial Blocklist](https://wicg.github.io/serial/#blocklist) used by Chromium and outlined in their respective specifications.
+
+To disable these, users can pass `disable-usb-blocklist` and `disable-serial-blocklist` as command line flags.
+
 ### Removed: `null` value for `session` property in `ProtocolResponse`
 
 This deprecated feature has been removed.
diff --git a/docs/tutorial/devices.md b/docs/tutorial/devices.md
index ae6d21ae6bd6..37af4e01fd2d 100644
--- a/docs/tutorial/devices.md
+++ b/docs/tutorial/devices.md
@@ -57,7 +57,7 @@ the WebHID API:
 
 ### Blocklist
 
-By default Electron employs the same [blocklist](https://github.com/WICG/webhid/blob/main/blocklist.txt)
+By default Electron employs the same [blocklist](https://wicg.github.io/webhid/#blocklist)
 used by Chromium.  If you wish to override this behavior, you can do so by
 setting the `disable-hid-blocklist` flag:
 
@@ -104,6 +104,16 @@ There are several additional APIs for working with the Web Serial API:
 * [`ses.setPermissionCheckHandler(handler)`](../api/session.md#sessetpermissioncheckhandlerhandler)
   can be used to disable serial access for specific origins.
 
+### Blocklist
+
+By default Electron employs the same [blocklist](https://wicg.github.io/serial/#blocklist)
+used by Chromium.  If you wish to override this behavior, you can do so by
+setting the `disable-serial-blocklist` flag:
+
+```js
+app.commandLine.appendSwitch('disable-serial-blocklist')
+```
+
 ### Example
 
 This example demonstrates an Electron application that automatically selects
@@ -145,6 +155,16 @@ Electron provides several APIs for working with the WebUSB API:
 * [`ses.setUSBProtectedClassesHandler](../api/session.md#sessetusbprotectedclasseshandlerhandler)
   can be used to allow usage of [protected USB classes](https://wicg.github.io/webusb/#usbinterface-interface) that are not available by default.
 
+### Blocklist
+
+By default Electron employs the same [blocklist](https://wicg.github.io/webusb/#blocklist)
+used by Chromium.  If you wish to override this behavior, you can do so by
+setting the `disable-usb-blocklist` flag:
+
+```js
+app.commandLine.appendSwitch('disable-usb-blocklist')
+```
+
 ### Example
 
 This example demonstrates an Electron application that automatically selects
diff --git a/shell/browser/serial/serial_chooser_context.cc b/shell/browser/serial/serial_chooser_context.cc
index be387c644e9a..c0ae6ed24851 100644
--- a/shell/browser/serial/serial_chooser_context.cc
+++ b/shell/browser/serial/serial_chooser_context.cc
@@ -9,7 +9,9 @@
 #include <utility>
 
 #include "base/base64.h"
+#include "base/command_line.h"
 #include "base/values.h"
+#include "chrome/browser/serial/serial_blocklist.h"
 #include "content/public/browser/device_service.h"
 #include "content/public/browser/web_contents.h"
 #include "mojo/public/cpp/bindings/pending_remote.h"
@@ -104,6 +106,12 @@ bool SerialChooserContext::HasPortPermission(
     const url::Origin& origin,
     const device::mojom::SerialPortInfo& port,
     content::RenderFrameHost* render_frame_host) {
+  bool blocklist_disabled = base::CommandLine::ForCurrentProcess()->HasSwitch(
+      kDisableSerialBlocklist);
+  if (!blocklist_disabled && SerialBlocklist::Get().IsExcluded(port)) {
+    return false;
+  }
+
   auto it = ephemeral_ports_.find(origin);
   if (it != ephemeral_ports_.end()) {
     const std::set<base::UnguessableToken>& ports = it->second;
diff --git a/shell/browser/serial/serial_chooser_context.h b/shell/browser/serial/serial_chooser_context.h
index 0dbeb15dc81f..100287e52e25 100644
--- a/shell/browser/serial/serial_chooser_context.h
+++ b/shell/browser/serial/serial_chooser_context.h
@@ -36,6 +36,8 @@ namespace electron {
 
 class ElectronBrowserContext;
 
+const char kDisableSerialBlocklist[] = "disable-serial-blocklist";
+
 inline constexpr std::string_view kPortNameKey = "name";
 inline constexpr std::string_view kTokenKey = "token";
 inline constexpr std::string_view kBluetoothDevicePathKey =
diff --git a/shell/browser/serial/serial_chooser_controller.cc b/shell/browser/serial/serial_chooser_controller.cc
index 9ab960a3b978..217f495fd02a 100644
--- a/shell/browser/serial/serial_chooser_controller.cc
+++ b/shell/browser/serial/serial_chooser_controller.cc
@@ -7,9 +7,12 @@
 #include <algorithm>
 #include <utility>
 
+#include "base/command_line.h"
 #include "base/containers/contains.h"
 #include "base/functional/bind.h"
 #include "base/strings/string_number_conversions.h"
+#include "chrome/browser/serial/serial_blocklist.h"
+#include "content/public/browser/console_message.h"
 #include "content/public/browser/web_contents.h"
 #include "device/bluetooth/bluetooth_adapter.h"
 #include "device/bluetooth/bluetooth_adapter_factory.h"
@@ -120,8 +123,7 @@ SerialChooserController::SerialChooserController(
       allowed_bluetooth_service_class_ids_(
           std::move(allowed_bluetooth_service_class_ids)),
       callback_(std::move(callback)),
-      serial_delegate_(serial_delegate),
-      render_frame_host_id_(render_frame_host->GetGlobalId()) {
+      initiator_document_(render_frame_host->GetWeakDocumentPtr()) {
   origin_ = web_contents_->GetPrimaryMainFrame()->GetLastCommittedOrigin();
 
   chooser_context_ = SerialChooserContextFactory::GetForBrowserContext(
@@ -210,7 +212,7 @@ void SerialChooserController::OnDeviceChosen(const std::string& port_id) {
       return ptr->token.ToString() == port_id;
     });
     if (it != ports_.end()) {
-      auto* rfh = content::RenderFrameHost::FromID(render_frame_host_id_);
+      auto* rfh = initiator_document_.AsRenderFrameHostIfValid();
       chooser_context_->GrantPortPermission(origin_, *it->get(), rfh);
       RunCallback(it->Clone());
     } else {
@@ -246,6 +248,34 @@ void SerialChooserController::OnGetDevices(
 
 bool SerialChooserController::DisplayDevice(
     const device::mojom::SerialPortInfo& port) const {
+  bool blocklist_disabled = base::CommandLine::ForCurrentProcess()->HasSwitch(
+      kDisableSerialBlocklist);
+  if (!blocklist_disabled && SerialBlocklist::Get().IsExcluded(port)) {
+    if (port.has_vendor_id && port.has_product_id) {
+      AddMessageToConsole(
+          blink::mojom::ConsoleMessageLevel::kInfo,
+          base::StringPrintf(
+              "Skipping a port blocked by "
+              "the Serial blocklist: vendorId=%d, "
+              "productId=%d, name='%s', serial='%s'",
+              port.vendor_id, port.product_id,
+              port.display_name ? port.display_name.value().c_str() : "",
+              port.serial_number ? port.serial_number.value().c_str() : ""));
+    } else if (port.bluetooth_service_class_id) {
+      AddMessageToConsole(
+          blink::mojom::ConsoleMessageLevel::kInfo,
+          base::StringPrintf(
+              "Skipping a port blocked by "
+              "the Serial blocklist: bluetoothServiceClassId=%s, "
+              "name='%s'",
+              port.bluetooth_service_class_id->value().c_str(),
+              port.display_name ? port.display_name.value().c_str() : ""));
+    } else {
+      NOTREACHED();
+    }
+    return false;
+  }
+
   if (filters_.empty()) {
     return BluetoothPortIsAllowed(allowed_bluetooth_service_class_ids_, port);
   }
@@ -260,6 +290,15 @@ bool SerialChooserController::DisplayDevice(
   return false;
 }
 
+void SerialChooserController::AddMessageToConsole(
+    blink::mojom::ConsoleMessageLevel level,
+    const std::string& message) const {
+  if (content::RenderFrameHost* rfh =
+          initiator_document_.AsRenderFrameHostIfValid()) {
+    rfh->AddMessageToConsole(level, message);
+  }
+}
+
 void SerialChooserController::RunCallback(
     device::mojom::SerialPortInfoPtr port) {
   if (callback_) {
diff --git a/shell/browser/serial/serial_chooser_controller.h b/shell/browser/serial/serial_chooser_controller.h
index e88db05bb80e..b030be80c8c0 100644
--- a/shell/browser/serial/serial_chooser_controller.h
+++ b/shell/browser/serial/serial_chooser_controller.h
@@ -12,9 +12,11 @@
 #include "base/scoped_observation.h"
 #include "content/public/browser/global_routing_id.h"
 #include "content/public/browser/serial_chooser.h"
+#include "content/public/browser/weak_document_ptr.h"
 #include "device/bluetooth/bluetooth_adapter.h"
 #include "services/device/public/mojom/serial.mojom-forward.h"
 #include "shell/browser/serial/serial_chooser_context.h"
+#include "third_party/blink/public/mojom/devtools/console_message.mojom.h"
 #include "third_party/blink/public/mojom/serial/serial.mojom-forward.h"
 
 namespace content {
@@ -66,6 +68,8 @@ class SerialChooserController final
   void GetDevices();
   void OnGetDevices(std::vector<device::mojom::SerialPortInfoPtr> ports);
   bool DisplayDevice(const device::mojom::SerialPortInfo& port) const;
+  void AddMessageToConsole(blink::mojom::ConsoleMessageLevel level,
+                           const std::string& message) const;
   void RunCallback(device::mojom::SerialPortInfoPtr port);
   void OnDeviceChosen(const std::string& port_id);
   void OnGetAdapter(base::OnceClosure callback,
@@ -78,6 +82,7 @@ class SerialChooserController final
   std::vector<blink::mojom::SerialPortFilterPtr> filters_;
   std::vector<::device::BluetoothUUID> allowed_bluetooth_service_class_ids_;
   content::SerialChooser::Callback callback_;
+  content::WeakDocumentPtr initiator_document_;
   url::Origin origin_;
 
   base::WeakPtr<SerialChooserContext> chooser_context_;
diff --git a/shell/browser/usb/usb_chooser_context.cc b/shell/browser/usb/usb_chooser_context.cc
index 1273b7dbd41e..1cb603734924 100644
--- a/shell/browser/usb/usb_chooser_context.cc
+++ b/shell/browser/usb/usb_chooser_context.cc
@@ -8,9 +8,11 @@
 #include <utility>
 #include <vector>
 
+#include "base/command_line.h"
 #include "base/functional/bind.h"
 #include "base/task/sequenced_task_runner.h"
 #include "base/values.h"
+#include "chrome/browser/usb/usb_blocklist.h"
 #include "components/content_settings/core/common/content_settings.h"
 #include "content/public/browser/device_service.h"
 #include "services/device/public/cpp/usb/usb_ids.h"
@@ -215,6 +217,12 @@ void UsbChooserContext::GrantDevicePermission(
 bool UsbChooserContext::HasDevicePermission(
     const url::Origin& origin,
     const device::mojom::UsbDeviceInfo& device_info) {
+  bool blocklist_disabled =
+      base::CommandLine::ForCurrentProcess()->HasSwitch(kDisableUSBBlocklist);
+  if (!blocklist_disabled && UsbBlocklist::Get().IsExcluded(device_info)) {
+    return false;
+  }
+
   auto it = ephemeral_devices_.find(origin);
   if (it != ephemeral_devices_.end() && it->second.contains(device_info.guid)) {
     return true;
diff --git a/shell/browser/usb/usb_chooser_context.h b/shell/browser/usb/usb_chooser_context.h
index d62c9ad5edfb..1f1929b4168c 100644
--- a/shell/browser/usb/usb_chooser_context.h
+++ b/shell/browser/usb/usb_chooser_context.h
@@ -33,6 +33,8 @@ namespace electron {
 
 class ElectronBrowserContext;
 
+const char kDisableUSBBlocklist[] = "disable-usb-blocklist";
+
 class UsbChooserContext : public KeyedService,
                           public device::mojom::UsbDeviceManagerClient {
  public:
diff --git a/shell/browser/usb/usb_chooser_controller.cc b/shell/browser/usb/usb_chooser_controller.cc
index ccc8c8c2bb11..d786846a0e86 100644
--- a/shell/browser/usb/usb_chooser_controller.cc
+++ b/shell/browser/usb/usb_chooser_controller.cc
@@ -8,7 +8,9 @@
 #include <cstddef>
 #include <utility>
 
+#include "base/command_line.h"
 #include "base/functional/bind.h"
+#include "chrome/browser/usb/usb_blocklist.h"
 #include "components/strings/grit/components_strings.h"
 #include "content/public/browser/render_frame_host.h"
 #include "content/public/browser/web_contents.h"
@@ -140,6 +142,8 @@ void UsbChooserController::GotUsbDeviceList(
 
 bool UsbChooserController::DisplayDevice(
     const device::mojom::UsbDeviceInfo& device_info) const {
+  bool blocklist_disabled =
+      base::CommandLine::ForCurrentProcess()->HasSwitch(kDisableUSBBlocklist);
   if (!device::UsbDeviceFilterMatchesAny(options_->filters, device_info)) {
     return false;
   }
@@ -151,6 +155,10 @@ bool UsbChooserController::DisplayDevice(
     return false;
   }
 
+  if (!blocklist_disabled && UsbBlocklist::Get().IsExcluded(device_info)) {
+    return false;
+  }
+
   return true;
 }