diff --git a/shell/renderer/renderer_client_base.cc b/shell/renderer/renderer_client_base.cc
index ba4676bf7877..77e766cd2b45 100644
--- a/shell/renderer/renderer_client_base.cc
+++ b/shell/renderer/renderer_client_base.cc
@@ -361,11 +361,8 @@ bool RendererClientBase::IsPluginHandledExternally(
 
 bool RendererClientBase::IsOriginIsolatedPepperPlugin(
     const base::FilePath& plugin_path) {
-#if BUILDFLAG(ENABLE_PDF_VIEWER)
-  return plugin_path.value() == kPdfPluginPath;
-#else
-  return false;
-#endif
+  // Isolate all Pepper plugins, including the PDF plugin.
+  return true;
 }
 
 std::unique_ptr<blink::WebPrescientNetworking>