diff --git a/atom/common/api/atom_bindings.cc b/atom/common/api/atom_bindings.cc
index fcb65e73969d..3f274cc1c11e 100644
--- a/atom/common/api/atom_bindings.cc
+++ b/atom/common/api/atom_bindings.cc
@@ -4,6 +4,7 @@
 
 #include "atom/common/api/atom_bindings.h"
 
+#include <algorithm>
 #include <string>
 
 #include "atom/common/atom_version.h"
@@ -18,9 +19,6 @@ namespace atom {
 
 namespace {
 
-// Async handle to wake up uv loop.
-uv_async_t g_next_tick_uv_handle;
-
 // Async handle to execute the stored v8 callback.
 uv_async_t g_callback_uv_handle;
 
@@ -30,25 +28,6 @@ base::Closure g_v8_callback;
 // Dummy class type that used for crashing the program.
 struct DummyClass { bool crash; };
 
-// Async handler to call next process.nextTick callbacks.
-void UvCallNextTick(uv_async_t* handle) {
-  v8::Isolate* isolate = v8::Isolate::GetCurrent();
-  node::Environment* env = node::Environment::GetCurrent(isolate);
-  node::Environment::TickInfo* tick_info = env->tick_info();
-
-  if (tick_info->in_tick())
-    return;
-
-  if (tick_info->length() == 0) {
-    tick_info->set_index(0);
-    return;
-  }
-
-  tick_info->set_in_tick(true);
-  env->tick_callback_function()->Call(env->process_object(), 0, NULL);
-  tick_info->set_in_tick(false);
-}
-
 // Async handler to execute the stored v8 callback.
 void UvOnCallback(uv_async_t* handle) {
   g_v8_callback.Run();
@@ -65,10 +44,6 @@ void FatalErrorCallback(const char* location, const char* message) {
   Crash();
 }
 
-void ActivateUVLoop() {
-  uv_async_send(&g_next_tick_uv_handle);
-}
-
 void Log(const base::string16& message) {
   logging::LogMessage("CONSOLE", 0, 0).stream() << message;
 }
@@ -82,7 +57,9 @@ void ScheduleCallback(const base::Closure& callback) {
 
 
 AtomBindings::AtomBindings() {
-  uv_async_init(uv_default_loop(), &g_next_tick_uv_handle, UvCallNextTick);
+  uv_async_init(uv_default_loop(), &call_next_tick_async_, OnCallNextTick);
+  call_next_tick_async_.data = this;
+
   uv_async_init(uv_default_loop(), &g_callback_uv_handle, UvOnCallback);
   v8::V8::SetFatalErrorHandler(FatalErrorCallback);
 }
@@ -94,9 +71,10 @@ void AtomBindings::BindTo(v8::Isolate* isolate,
                           v8::Handle<v8::Object> process) {
   mate::Dictionary dict(isolate, process);
   dict.SetMethod("crash", &Crash);
-  dict.SetMethod("activateUvLoop", &ActivateUVLoop);
   dict.SetMethod("log", &Log);
   dict.SetMethod("scheduleCallback", &ScheduleCallback);
+  dict.SetMethod("activateUvLoop",
+      base::Bind(&AtomBindings::ActivateUVLoop, base::Unretained(this)));
 
   v8::Handle<v8::Object> versions;
   if (dict.Get("versions", &versions))
@@ -104,4 +82,40 @@ void AtomBindings::BindTo(v8::Isolate* isolate,
                   mate::StringToV8(isolate, ATOM_VERSION_STRING));
 }
 
+void AtomBindings::ActivateUVLoop(v8::Isolate* isolate) {
+  node::Environment* env = node::Environment::GetCurrent(isolate);
+  if (std::find(pending_next_ticks_.begin(), pending_next_ticks_.end(), env) !=
+      pending_next_ticks_.end())
+    return;
+
+  pending_next_ticks_.push_back(env);
+  uv_async_send(&call_next_tick_async_);
+}
+
+// static
+void AtomBindings::OnCallNextTick(uv_async_t* handle) {
+  AtomBindings* self = static_cast<AtomBindings*>(handle->data);
+  for (std::list<node::Environment*>::const_iterator it =
+           self->pending_next_ticks_.begin();
+       it != self->pending_next_ticks_.end(); ++it) {
+    node::Environment* env = *it;
+    node::Environment::TickInfo* tick_info = env->tick_info();
+
+    v8::Context::Scope context_scope(env->context());
+    if (tick_info->in_tick())
+      continue;
+
+    if (tick_info->length() == 0) {
+      tick_info->set_index(0);
+      continue;
+    }
+
+    tick_info->set_in_tick(true);
+    env->tick_callback_function()->Call(env->process_object(), 0, NULL);
+    tick_info->set_in_tick(false);
+  }
+
+  self->pending_next_ticks_.clear();
+}
+
 }  // namespace atom
diff --git a/atom/common/api/atom_bindings.h b/atom/common/api/atom_bindings.h
index fadb535848f2..807ffcfc1cce 100644
--- a/atom/common/api/atom_bindings.h
+++ b/atom/common/api/atom_bindings.h
@@ -5,8 +5,15 @@
 #ifndef ATOM_COMMON_API_ATOM_BINDINGS_H_
 #define ATOM_COMMON_API_ATOM_BINDINGS_H_
 
+#include <list>
+
 #include "base/strings/string16.h"
 #include "v8/include/v8.h"
+#include "vendor/node/deps/uv/include/uv.h"
+
+namespace node {
+class Environment;
+}
 
 namespace atom {
 
@@ -20,6 +27,13 @@ class AtomBindings {
   virtual void BindTo(v8::Isolate* isolate, v8::Handle<v8::Object> process);
 
  private:
+  void ActivateUVLoop(v8::Isolate* isolate);
+
+  static void OnCallNextTick(uv_async_t* handle);
+
+  uv_async_t call_next_tick_async_;
+  std::list<node::Environment*> pending_next_ticks_;
+
   DISALLOW_COPY_AND_ASSIGN(AtomBindings);
 };