diff --git a/atom/renderer/atom_renderer_client.cc b/atom/renderer/atom_renderer_client.cc
index 79aea0ee0b5f..cbea7f7a5660 100644
--- a/atom/renderer/atom_renderer_client.cc
+++ b/atom/renderer/atom_renderer_client.cc
@@ -206,7 +206,8 @@ std::vector<std::string> ParseSchemesCLISwitch(const char* switch_name) {
 }  // namespace
 
 AtomRendererClient::AtomRendererClient()
-    : node_bindings_(NodeBindings::Create(false)),
+    : node_integration_initialized_(false),
+      node_bindings_(NodeBindings::Create(false)),
       atom_bindings_(new AtomBindings) {
   isolated_world_ = base::CommandLine::ForCurrentProcess()->HasSwitch(
       switches::kContextIsolation);
@@ -342,11 +343,9 @@ void AtomRendererClient::DidCreateScriptContext(
   if (!render_frame->IsMainFrame() && !IsDevToolsExtension(render_frame))
     return;
 
-  // Whether the node binding has been initialized.
-  bool first_time = node_bindings_->uv_env() == nullptr;
-
   // Prepare the node bindings.
-  if (first_time) {
+  if (!node_integration_initialized_) {
+    node_integration_initialized_ = true;
     node_bindings_->Initialize();
     node_bindings_->PrepareMessageLoop();
   }
@@ -362,7 +361,7 @@ void AtomRendererClient::DidCreateScriptContext(
   // Load everything.
   node_bindings_->LoadEnvironment(env);
 
-  if (first_time) {
+  if (node_bindings_->uv_env() == nullptr) {
     // Make uv loop being wrapped by window context.
     node_bindings_->set_uv_env(env);
 
@@ -382,6 +381,10 @@ void AtomRendererClient::WillReleaseScriptContext(
   if (env)
     mate::EmitEvent(env->isolate(), env->process_object(), "exit");
 
+  // The main frame may be replaced.
+  if (env == node_bindings_->uv_env())
+    node_bindings_->set_uv_env(nullptr);
+
   // Destroy the node environment.
   node::FreeEnvironment(env);
   atom_bindings_->EnvironmentDestroyed(env);
diff --git a/atom/renderer/atom_renderer_client.h b/atom/renderer/atom_renderer_client.h
index a693262fed1b..c1d86cddf5e3 100644
--- a/atom/renderer/atom_renderer_client.h
+++ b/atom/renderer/atom_renderer_client.h
@@ -66,6 +66,9 @@ class AtomRendererClient : public content::ContentRendererClient {
       std::vector<std::unique_ptr<::media::KeySystemProperties>>* key_systems)
       override;
 
+  // Whether the node integration has been initialized.
+  bool node_integration_initialized_;
+
   std::unique_ptr<NodeBindings> node_bindings_;
   std::unique_ptr<AtomBindings> atom_bindings_;
   std::unique_ptr<PreferencesManager> preferences_manager_;