diff --git a/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestApp/Program.cs b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestApp/Program.cs
new file mode 100644
index 000000000..a168da37c
--- /dev/null
+++ b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestApp/Program.cs
@@ -0,0 +1,15 @@
+// Copyright (c) .NET Foundation and contributors. All rights reserved.
+// Licensed under the MIT license. See LICENSE file in the project root for full license information.
+
+using System;
+
+namespace TestApp
+{
+    class Program
+    {
+        public static void Main(string[] args)
+         {
+             Console.WriteLine(TestLibrary.Helper.GetMessage());
+         }
+    }
+}
diff --git a/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestApp/TestApp.csproj b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestApp/TestApp.csproj
new file mode 100644
index 000000000..4f3707aba
--- /dev/null
+++ b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestApp/TestApp.csproj
@@ -0,0 +1,12 @@
+<Project Sdk="Microsoft.NET.Sdk">
+
+  <PropertyGroup>
+    <OutputType>Exe</OutputType>
+    <TargetFramework>net461</TargetFramework>
+  </PropertyGroup>
+
+    <ItemGroup>
+    <ProjectReference Include="..\TestLibrary\TestLibrary.csproj" />
+  </ItemGroup>
+
+</Project>
diff --git a/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestLibrary/Helper.cs b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestLibrary/Helper.cs
new file mode 100644
index 000000000..67b32cfdb
--- /dev/null
+++ b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestLibrary/Helper.cs
@@ -0,0 +1,24 @@
+// Copyright (c) .NET Foundation and contributors. All rights reserved.
+// Licensed under the MIT license. See LICENSE file in the project root for full license information.
+
+using System;
+
+namespace TestLibrary
+{
+    public static class Helper
+    {
+        /// <summary>
+        /// Gets the message from the helper. This comment is here to help test XML documentation file generation, please do not remove it.
+        /// </summary>
+        /// <returns>A message</returns>
+        public static string GetMessage()
+        {
+            return "This string came from the test library!";
+        }
+
+        public static void SayHi()
+        {
+            Console.WriteLine("Hello there!");
+        }
+    }
+}
\ No newline at end of file
diff --git a/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestLibrary/TestLibrary.csproj b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestLibrary/TestLibrary.csproj
new file mode 100644
index 000000000..9f5c4f4ab
--- /dev/null
+++ b/TestAssets/DesktopTestProjects/NETFrameworkReferenceNETStandard20/TestLibrary/TestLibrary.csproj
@@ -0,0 +1,7 @@
+<Project Sdk="Microsoft.NET.Sdk">
+
+  <PropertyGroup>
+    <TargetFramework>netstandard2.0</TargetFramework>
+  </PropertyGroup>
+
+</Project>
diff --git a/test/EndToEnd/GivenNetFrameworkSupportsNetStandard2.cs b/test/EndToEnd/GivenNetFrameworkSupportsNetStandard2.cs
new file mode 100644
index 000000000..97398a685
--- /dev/null
+++ b/test/EndToEnd/GivenNetFrameworkSupportsNetStandard2.cs
@@ -0,0 +1,40 @@
+using FluentAssertions;
+using Microsoft.DotNet.TestFramework;
+using Microsoft.DotNet.Tools.Test.Utilities;
+using System;
+using System.Collections.Generic;
+using System.IO;
+using System.Text;
+
+namespace EndToEnd
+{
+    public class GivenNetFrameworkSupportsNetStandard2 : TestBase
+    {
+        [WindowsOnlyFact]
+        public void ANET461ProjectCanReferenceANETStandardProject()
+        {
+            var _testInstance = TestAssets.Get(TestAssetKinds.DesktopTestProjects, "NETFrameworkReferenceNETStandard20")
+                .CreateInstance()
+                .WithSourceFiles();
+
+            string projectDirectory = Path.Combine(_testInstance.Root.FullName, "TestApp");
+
+            new RestoreCommand()
+                .WithWorkingDirectory(projectDirectory)
+                .Execute()
+                .Should().Pass();
+
+            new BuildCommand()
+                .WithWorkingDirectory(projectDirectory)
+                .Execute()
+                .Should().Pass();
+
+            new RunCommand()
+                    .WithWorkingDirectory(projectDirectory)
+                    .ExecuteWithCapturedOutput()
+                    .Should().Pass()
+                         .And.HaveStdOutContaining("This string came from the test library!");
+
+        }
+    }
+}