diff --git a/eng/pipelines/templates/stages/vmr-build.yml b/eng/pipelines/templates/stages/vmr-build.yml
index e6ae84bdc..3825ce22f 100644
--- a/eng/pipelines/templates/stages/vmr-build.yml
+++ b/eng/pipelines/templates/stages/vmr-build.yml
@@ -747,6 +747,59 @@ stages:
             targetOS: linux
             targetArchitecture: arm64
 
+        - template: ../jobs/vmr-build.yml
+          parameters:
+            buildName: Mariner_x64_Cross_Alpine
+            isBuiltFromVmr: ${{ parameters.isBuiltFromVmr }}
+            vmrBranch: ${{ variables.VmrBranch }}
+            architecture: x64
+            pool: ${{ parameters.pool_Linux }}
+            container: ${{ variables.marinerX64AlpineCrossContainer }}
+            crossRootFs: '/crossrootfs/x64'
+            targetOS: linux-musl
+            targetArchitecture: x64
+            extraProperties: /p:TargetRID=linux-musl-x64
+
+        - template: ../jobs/vmr-build.yml
+          parameters:
+            buildName: Mariner_x64_Cross_Alpine_Mono
+            isBuiltFromVmr: ${{ parameters.isBuiltFromVmr }}
+            vmrBranch: ${{ variables.VmrBranch }}
+            architecture: x64
+            pool: ${{ parameters.pool_Linux }}
+            container: ${{ variables.marinerX64AlpineCrossContainer }}
+            crossRootFs: '/crossrootfs/x64'
+            useMonoRuntime: true
+            targetOS: linux-musl
+            targetArchitecture: x64
+            extraProperties: /p:TargetRID=linux-musl-x64
+
+        - template: ../jobs/vmr-build.yml
+          parameters:
+            buildName: Mariner_x64_Cross_Alpine
+            isBuiltFromVmr: ${{ parameters.isBuiltFromVmr }}
+            vmrBranch: ${{ variables.VmrBranch }}
+            architecture: arm
+            pool: ${{ parameters.pool_Linux }}
+            container: ${{ variables.marinerArmAlpineCrossContainer }}
+            crossRootFs: '/crossrootfs/arm'
+            targetOS: linux-musl
+            targetArchitecture: arm
+            extraProperties: /p:TargetRID=linux-musl-arm
+
+        - template: ../jobs/vmr-build.yml
+          parameters:
+            buildName: Mariner_x64_Cross_Alpine
+            isBuiltFromVmr: ${{ parameters.isBuiltFromVmr }}
+            vmrBranch: ${{ variables.VmrBranch }}
+            architecture: arm64
+            pool: ${{ parameters.pool_Linux }}
+            container: ${{ variables.marinerArm64AlpineCrossContainer }}
+            crossRootFs: '/crossrootfs/arm64'
+            targetOS: linux-musl
+            targetArchitecture: arm64
+            extraProperties: /p:TargetRID=linux-musl-arm64
+
         - template: ../jobs/vmr-build.yml
           parameters:
             buildName: OSX
diff --git a/eng/pipelines/templates/variables/vmr-build.yml b/eng/pipelines/templates/variables/vmr-build.yml
index 6db4202d9..9315ac61c 100644
--- a/eng/pipelines/templates/variables/vmr-build.yml
+++ b/eng/pipelines/templates/variables/vmr-build.yml
@@ -26,6 +26,12 @@ variables:
   value: mcr.microsoft.com/dotnet-buildtools/prereqs:cbl-mariner-2.0-cross-arm
 - name: marinerArm64CrossContainer
   value: mcr.microsoft.com/dotnet-buildtools/prereqs:cbl-mariner-2.0-cross-arm64
+- name: marinerX64AlpineCrossContainer
+  value: mcr.microsoft.com/dotnet-buildtools/prereqs:cbl-mariner-2.0-cross-amd64-alpine
+- name: marinerArmAlpineCrossContainer
+  value: mcr.microsoft.com/dotnet-buildtools/prereqs:cbl-mariner-2.0-cross-arm-alpine
+- name: marinerArm64AlpineCrossContainer
+  value: mcr.microsoft.com/dotnet-buildtools/prereqs:cbl-mariner-2.0-cross-arm64-alpine
 - name: androidCrossContainer
   value: mcr.microsoft.com/dotnet-buildtools/prereqs:cbl-mariner-2.0-cross-android-amd64
 - name: browserCrossContainer
diff --git a/src/SourceBuild/content/repo-projects/runtime.proj b/src/SourceBuild/content/repo-projects/runtime.proj
index 318fe6ad0..94e18fb7e 100644
--- a/src/SourceBuild/content/repo-projects/runtime.proj
+++ b/src/SourceBuild/content/repo-projects/runtime.proj
@@ -15,8 +15,8 @@
     <BuildArgs>$(BuildArgs) $(FlagParameterPrefix)arch $(TargetArchitecture)</BuildArgs>
     <BuildArgs>$(BuildArgs) $(FlagParameterPrefix)os $(TargetOS)</BuildArgs>
     <BuildArgs>$(BuildArgs) /p:TargetRid=$(TargetRid)</BuildArgs>
-    <BuildArgs Condition="'$(ShortStack)' != 'true'">$(BuildArgs) /p:RuntimeOS=$(RuntimeOS)</BuildArgs>
-    <BuildArgs Condition="'$(ShortStack)' != 'true'">$(BuildArgs) /p:BaseOS=$(BaseOS)</BuildArgs>
+    <BuildArgs Condition="'$(ShortStack)' != 'true' and '$(TargetOS)' != 'linux-musl'">$(BuildArgs) /p:RuntimeOS=$(RuntimeOS)</BuildArgs>
+    <BuildArgs Condition="'$(ShortStack)' != 'true' and '$(TargetOS)' != 'linux-musl'">$(BuildArgs) /p:BaseOS=$(BaseOS)</BuildArgs>
     <BuildArgs Condition="'$(DotNetBuildRuntimeWasmEnableThreads)' == 'true'">$(BuildArgs) /p:DotNetBuildRuntimeWasmEnableThreads=true</BuildArgs>
     <BuildArgs Condition="'$(DotNetBuildRuntimeNativeAOTRuntimePack)' == 'true'">$(BuildArgs) /p:DotNetBuildRuntimeNativeAOTRuntimePack=true</BuildArgs>
     <BuildArgs Condition="'$(PgoInstrument)' == 'true'">$(BuildArgs) $(FlagParameterPrefix)pgoinstrument</BuildArgs>
diff --git a/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkAssemblyVersions-linux-musl-arm.diff b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkAssemblyVersions-linux-musl-arm.diff
new file mode 100644
index 000000000..e69de29bb
diff --git a/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkAssemblyVersions-linux-musl-arm64.diff b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkAssemblyVersions-linux-musl-arm64.diff
new file mode 100644
index 000000000..e69de29bb
diff --git a/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkAssemblyVersions-linux-musl-x64.diff b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkAssemblyVersions-linux-musl-x64.diff
new file mode 100644
index 000000000..e69de29bb
diff --git a/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-arm.diff b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-arm.diff
new file mode 100644
index 000000000..fff0fe82b
--- /dev/null
+++ b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-arm.diff
@@ -0,0 +1,20 @@
+diff --git a/msftSdkFiles.txt b/ubSdkFiles.txt
+index ------------
+--- a/msftSdkFiles.txt
++++ b/ubSdkFiles.txt
+@@ ------------ @@
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Diagnostics.EventLog.dll
++./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Diagnostics.EventLog.Messages.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Security.Cryptography.Pkcs.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Windows.Extensions.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/System.CodeDom.dll
+@@ ------------ @@
+ ./sdk/x.y.z/Microsoft.NET.Sdk.WorkloadMSBuildSdkResolver.dll
+ ./sdk/x.y.z/Microsoft.NET.StringTools.dll
+ ./sdk/x.y.z/Microsoft.NETCoreSdk.BundledCliTools.props
+-./sdk/x.y.z/Microsoft.NETCoreSdk.BundledMSBuildInformation.props
+ ./sdk/x.y.z/Microsoft.NETCoreSdk.BundledVersions.props
+ ./sdk/x.y.z/Microsoft.NETFramework.CurrentVersion.props
+ ./sdk/x.y.z/Microsoft.NETFramework.CurrentVersion.targets
diff --git a/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-arm64.diff b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-arm64.diff
new file mode 100644
index 000000000..fff0fe82b
--- /dev/null
+++ b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-arm64.diff
@@ -0,0 +1,20 @@
+diff --git a/msftSdkFiles.txt b/ubSdkFiles.txt
+index ------------
+--- a/msftSdkFiles.txt
++++ b/ubSdkFiles.txt
+@@ ------------ @@
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Diagnostics.EventLog.dll
++./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Diagnostics.EventLog.Messages.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Security.Cryptography.Pkcs.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Windows.Extensions.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/System.CodeDom.dll
+@@ ------------ @@
+ ./sdk/x.y.z/Microsoft.NET.Sdk.WorkloadMSBuildSdkResolver.dll
+ ./sdk/x.y.z/Microsoft.NET.StringTools.dll
+ ./sdk/x.y.z/Microsoft.NETCoreSdk.BundledCliTools.props
+-./sdk/x.y.z/Microsoft.NETCoreSdk.BundledMSBuildInformation.props
+ ./sdk/x.y.z/Microsoft.NETCoreSdk.BundledVersions.props
+ ./sdk/x.y.z/Microsoft.NETFramework.CurrentVersion.props
+ ./sdk/x.y.z/Microsoft.NETFramework.CurrentVersion.targets
diff --git a/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-x64.diff b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-x64.diff
new file mode 100644
index 000000000..fff0fe82b
--- /dev/null
+++ b/src/SourceBuild/content/test/Microsoft.DotNet.UnifiedBuild.Tests/assets/baselines/MsftToUbSdkFiles-linux-musl-x64.diff
@@ -0,0 +1,20 @@
+diff --git a/msftSdkFiles.txt b/ubSdkFiles.txt
+index ------------
+--- a/msftSdkFiles.txt
++++ b/ubSdkFiles.txt
+@@ ------------ @@
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Diagnostics.EventLog.dll
++./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Diagnostics.EventLog.Messages.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Security.Cryptography.Pkcs.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/runtimes/win/lib/netx.y/System.Windows.Extensions.dll
+ ./sdk/x.y.z/DotnetTools/dotnet-watch/x.y.z/tools/netx.y/any/System.CodeDom.dll
+@@ ------------ @@
+ ./sdk/x.y.z/Microsoft.NET.Sdk.WorkloadMSBuildSdkResolver.dll
+ ./sdk/x.y.z/Microsoft.NET.StringTools.dll
+ ./sdk/x.y.z/Microsoft.NETCoreSdk.BundledCliTools.props
+-./sdk/x.y.z/Microsoft.NETCoreSdk.BundledMSBuildInformation.props
+ ./sdk/x.y.z/Microsoft.NETCoreSdk.BundledVersions.props
+ ./sdk/x.y.z/Microsoft.NETFramework.CurrentVersion.props
+ ./sdk/x.y.z/Microsoft.NETFramework.CurrentVersion.targets