diff --git a/Microsoft.DotNet.Cli.sln b/Microsoft.DotNet.Cli.sln
index f3813694a..e16bf0d86 100644
--- a/Microsoft.DotNet.Cli.sln
+++ b/Microsoft.DotNet.Cli.sln
@@ -174,6 +174,8 @@ Project("{8BB2217D-0F2D-49D1-97BC-3654ED321F3B}") = "dotnet-test3.Tests", "test\
 EndProject
 Project("{FAE04EC0-301F-11D3-BF4B-00C04F79EFBC}") = "dotnet-cli-build", "build_projects\dotnet-cli-build\dotnet-cli-build.csproj", "{8A2FA2D8-0DA1-4814-B5C1-2ECEAA613EB1}"
 EndProject
+Project("{8BB2217D-0F2D-49D1-97BC-3654ED321F3B}") = "dotnet-run3.Tests", "test\dotnet-run3.Tests\dotnet-run3.Tests.xproj", "{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}"
+EndProject
 Global
 	GlobalSection(SolutionConfigurationPlatforms) = preSolution
 		Debug|Any CPU = Debug|Any CPU
@@ -1018,6 +1020,22 @@ Global
 		{8A2FA2D8-0DA1-4814-B5C1-2ECEAA613EB1}.RelWithDebInfo|Any CPU.Build.0 = Release|Any CPU
 		{8A2FA2D8-0DA1-4814-B5C1-2ECEAA613EB1}.RelWithDebInfo|x64.ActiveCfg = Release|Any CPU
 		{8A2FA2D8-0DA1-4814-B5C1-2ECEAA613EB1}.RelWithDebInfo|x64.Build.0 = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Debug|Any CPU.Build.0 = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Debug|x64.ActiveCfg = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Debug|x64.Build.0 = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.MinSizeRel|Any CPU.ActiveCfg = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.MinSizeRel|Any CPU.Build.0 = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.MinSizeRel|x64.ActiveCfg = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.MinSizeRel|x64.Build.0 = Debug|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Release|Any CPU.ActiveCfg = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Release|Any CPU.Build.0 = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Release|x64.ActiveCfg = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.Release|x64.Build.0 = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.RelWithDebInfo|Any CPU.ActiveCfg = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.RelWithDebInfo|Any CPU.Build.0 = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.RelWithDebInfo|x64.ActiveCfg = Release|Any CPU
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F}.RelWithDebInfo|x64.Build.0 = Release|Any CPU
 	EndGlobalSection
 	GlobalSection(SolutionProperties) = preSolution
 		HideSolutionNode = FALSE
@@ -1083,5 +1101,6 @@ Global
 		{FBE4F1D6-BA4C-46D9-8286-4EE4B032D01E} = {17735A9D-BFD9-4585-A7CB-3208CA6EA8A7}
 		{90236A80-4B84-41D3-A161-AA20709776B1} = {17735A9D-BFD9-4585-A7CB-3208CA6EA8A7}
 		{8A2FA2D8-0DA1-4814-B5C1-2ECEAA613EB1} = {88278B81-7649-45DC-8A6A-D3A645C5AFC3}
+		{9229D2A5-E2D1-4BEE-BC89-EFE65042842F} = {17735A9D-BFD9-4585-A7CB-3208CA6EA8A7}
 	EndGlobalSection
 EndGlobal
diff --git a/TestAssets/TestProjects/MSBuildAppWithMultipleFrameworks/MSBuildAppWithMultipleFrameworks.csproj b/TestAssets/TestProjects/MSBuildAppWithMultipleFrameworks/MSBuildAppWithMultipleFrameworks.csproj
new file mode 100644
index 000000000..abcd6d58c
--- /dev/null
+++ b/TestAssets/TestProjects/MSBuildAppWithMultipleFrameworks/MSBuildAppWithMultipleFrameworks.csproj
@@ -0,0 +1,28 @@
+<?xml version="1.0" encoding="utf-8"?>
+<Project ToolsVersion="14.0" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+  <Import Project="$(MSBuildExtensionsPath)\$(MSBuildToolsVersion)\Microsoft.Common.props" />
+
+  <PropertyGroup>
+    <OutputType>Exe</OutputType>
+    <TargetFrameworks>net451;netcoreapp1.0</TargetFrameworks>
+  </PropertyGroup>
+
+  <ItemGroup>
+    <PackageReference Include="Microsoft.NET.Sdk">
+      <Version>1.0.0-alpha-20161010-1</Version>
+      <PrivateAssets>All</PrivateAssets>
+    </PackageReference>
+  </ItemGroup>
+  <ItemGroup Condition=" '$(TargetFramework)' == 'netcoreapp1.0' ">
+    <PackageReference Include="Microsoft.NETCore.App">
+      <Version>1.0.1</Version>
+    </PackageReference>
+  </ItemGroup>
+
+  <ItemGroup>
+    <Compile Include="**\*.cs" />
+    <EmbeddedResource Include="**\*.resx" />
+  </ItemGroup>
+
+  <Import Project="$(MSBuildToolsPath)\Microsoft.CSharp.targets" />
+</Project>
\ No newline at end of file
diff --git a/TestAssets/TestProjects/MSBuildAppWithMultipleFrameworks/Program.cs b/TestAssets/TestProjects/MSBuildAppWithMultipleFrameworks/Program.cs
new file mode 100644
index 000000000..f5f4b6d13
--- /dev/null
+++ b/TestAssets/TestProjects/MSBuildAppWithMultipleFrameworks/Program.cs
@@ -0,0 +1,12 @@
+using System;
+
+namespace ConsoleApplication
+{
+    public class Program
+    {
+        public static void Main()
+        {
+            Console.WriteLine("Hello World!");
+        }
+    }
+}
diff --git a/test/dotnet-run3.Tests/GivenDotnetRun3RunsCsProj.cs b/test/dotnet-run3.Tests/GivenDotnetRun3RunsCsProj.cs
index 62183ef9e..5583ea382 100644
--- a/test/dotnet-run3.Tests/GivenDotnetRun3RunsCsProj.cs
+++ b/test/dotnet-run3.Tests/GivenDotnetRun3RunsCsProj.cs
@@ -87,5 +87,31 @@ namespace Microsoft.DotNet.Cli.Run3.Tests
                 .And
                 .HaveStdOutContaining("Hello World!");            
         }
+
+        [Fact]
+        public void ItReportsAGoodErrorWhenProjectHasMultipleFrameworks()
+        {
+            var testAppName = "MSBuildAppWithMultipleFrameworks";
+            var testInstance = TestAssetsManager
+                .CreateTestInstance(testAppName);
+
+            var testProjectDirectory = testInstance.TestRoot;
+
+            new Restore3Command()
+                .WithWorkingDirectory(testProjectDirectory)
+                .Execute()
+                .Should()
+                .Pass();
+
+            // use --no-build so this test can run on all platforms.
+            // the test app targets net451, which can't be built on non-Windows
+            new Run3Command()
+                .WithWorkingDirectory(testProjectDirectory)
+                .ExecuteWithCapturedOutput("--no-build")
+                .Should()
+                .Fail()
+                .And
+                .HaveStdErrContaining("--framework");
+        }
     }
 }
\ No newline at end of file
diff --git a/test/dotnet-run3.Tests/dotnet-run3.Tests.xproj b/test/dotnet-run3.Tests/dotnet-run3.Tests.xproj
new file mode 100644
index 000000000..781162867
--- /dev/null
+++ b/test/dotnet-run3.Tests/dotnet-run3.Tests.xproj
@@ -0,0 +1,18 @@
+<?xml version="1.0" encoding="utf-8"?>
+<Project ToolsVersion="14.0.24720" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+  <PropertyGroup>
+    <VisualStudioVersion Condition="'$(VisualStudioVersion)' == ''">14.0.24720</VisualStudioVersion>
+    <VSToolsPath Condition="'$(VSToolsPath)' == ''">$(MSBuildExtensionsPath32)\Microsoft\VisualStudio\v$(VisualStudioVersion)</VSToolsPath>
+  </PropertyGroup>
+  <Import Project="$(VSToolsPath)\DNX\Microsoft.DNX.Props" Condition="'$(VSToolsPath)' != ''" />
+  <PropertyGroup Label="Globals">
+    <ProjectGuid>9229D2A5-E2D1-4BEE-BC89-EFE65042842F</ProjectGuid>
+    <RootNamespace>Microsoft.DotNet.Cli.Run3.Tests</RootNamespace>
+    <BaseIntermediateOutputPath Condition="'$(BaseIntermediateOutputPath)'=='' ">..\..\artifacts\obj\$(MSBuildProjectName)</BaseIntermediateOutputPath>
+    <OutputPath Condition="'$(OutputPath)'=='' ">..\..\artifacts\bin</OutputPath>
+  </PropertyGroup>
+  <PropertyGroup>
+    <SchemaVersion>2.0</SchemaVersion>
+  </PropertyGroup>
+  <Import Project="$(VSToolsPath)\DNX\Microsoft.DNX.targets" Condition="'$(VSToolsPath)' != ''" />
+</Project>
\ No newline at end of file