diff --git a/run-build.ps1 b/run-build.ps1
index 4b0e5ab6d..e0e49bf4f 100644
--- a/run-build.ps1
+++ b/run-build.ps1
@@ -75,6 +75,9 @@ $env:DOTNET_SKIP_FIRST_TIME_EXPERIENCE=1
 # Don't resolve shared frameworks from user or global locations
 $env:DOTNET_MULTILEVEL_LOOKUP=0
 
+# Turn off MSBuild Node re-use
+$env:MSBUILDDISABLENODEREUSE=1
+
 # Enable vs test console logging
 $env:VSTEST_BUILD_TRACE=1
 $env:VSTEST_TRACE_BUILD=1
diff --git a/run-build.sh b/run-build.sh
index c136667a1..93214d658 100755
--- a/run-build.sh
+++ b/run-build.sh
@@ -151,6 +151,9 @@ export VSTEST_TRACE_BUILD=1
 # Don't resolve shared frameworks from user or global locations
 export DOTNET_MULTILEVEL_LOOKUP=0
 
+# Turn off MSBuild Node re-use
+export MSBUILDDISABLENODEREUSE=1
+
 # Install a stage 0
 INSTALL_ARCHITECTURE=$ARCHITECTURE
 archlower="$(echo $ARCHITECTURE | awk '{print tolower($0)}')"